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Hemoglobin A1c

Throughout the circulatory life of the red cell, Hemoglobin A1c is formed continuously by the adduction of glucose to the N-terminal of the hemoglobin beta chain. This process, which is non-enzymatic, reflects the average exposure of hemoglobin to glucose over an extended period. In a classical study, Trivelli et al showed Hemoglobin A1c in diabetic subjects to be elevated 2-3 fold over the levels found in normal individuals. Several investigators have recommended that Hemoglobin A1c serve as an indicator of metabolic control of the diabetic, since Hemoglobin A1c levels approach normal values for diabetics in metabolic control. Hemoglobin A1c has been defined operationally as the “fast fraction” hemoglobins (HbA1a, A1b, A1c) that elute first during column chromatography with cation-exchange resins. The non-glycosylated hemoglobin, which consists of the bulk of the hemoglobin has been designated HbA0. The present procedure utilizes a antigen and antibody reaction to directly determine the concentration of the HbA1c.


  • For the quantitative measurement of Hemoglobin A1c (HbA1c)
  • Fully automated sample pre-treatment on most analyzers
  • Single channel assay. Directly measures HbA1c
  • Assay range of 2.0%- 16%. NGSP Certified
  • No interference: HbS, HbA2 and HbC

Calibrator: Hemoglobin A1c Calibrator (Hb A1c)

Control: Hemoglobin A1c Control (Hb A1c)

Product Availability: Americas

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Name Part Size
HEMOGLOBIN A1c (HbA1c) H7546-40 1x30 mL (R1); 1x10 mL (R2); 1x125 mL Lyse
HEMOGLOBIN A1c (HbA1c) H7546-120 1x90 mL (R1); 1x30 mL (R2)

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