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Apolipoprotein

Lipoprotein is composed of lipids and proteins. The protein constituent is called apolipoprotein. Apolipoprotein AI (Apo AI) and apolipoprotein AII (Apo AII) comprise approximately 70% and 20%, respectively, of high-density lipoprotein (HDL). Apo AI activates LCAT. Apo AII has been shown to activate hepatic lipase and inhibit LCAT. As the concentration of Apo AI and Apo AII are independent, each must be assayed separately.

Apolipoprotein B is the major low density lipoprotein (LDL). Apo B is an integral component of the four major atherogenic lipoproteins: very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), low density lipoprotein (LDL), and lipoprotein (a). Apo B plays a major role in the recognition of cellular receptors for the catabolism of LDL. Apo B measurements are useful in the diagnosis of atherosclerosis. Numerous studies have indicated that apolipoprotein B may be useful in assessing coronary heart disease risk. Patients with coronary disease consistently have higher levels of Apo B than control values.

Apolipoprotein E (Apo E), a 34,000 dalton plasma protein, is found primarily in chylomicrons, VLDL, and HDL. Apo E serves as a ligand for lipoprotein receptors. Through its interaction with these receptors, Apo E is involved in the transport and metabolism of cholesterol and other lipids in the body. Accordingly, an apolipoprotein E assay can be used for studies involving secondary lipid metabolism disorders such as hereditary lipid metabolism disorder, arteriosclerosis, etc.

APOLIPOPROTEIN AI, AII, B, CII, CIII, E

  • For the quantitative measurement of human Apolipoproteins (Apo’s) by immunoturbidimetric assay.
  • Reagents are ready to use and do not require reconstitution.
  • Unopened reagents can be used for one year from date of manufacture, as indicated by the expiration date on package and bottle labels.
  • Opened reagents can be used for one month if stored at 2-8°C.

Product Availability: Americas

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Name Part Size
APOLIPOPROTEIN AI KAI-002 3x20 mL (R1); 1x20 mL (R2)
APOLIPOPROTEIN AII KAI-003 4x18mL (R1); 1x10 mL (R2)
APOLIPOPROTEIN B KAI-004 3x20 mL (R1); 1x20 mL (R2)
APOLIPOPROTEIN CII KAI-005 3x20 mL (R1); 1x20 mL (R2)
APOLIPOPROTEIN CIII KAI-006 3x20 mL (R1); 1x20 mL (R2)
APOLIPOPROTEIN E KAI-007 3x20 mL (R1); 1x20 mL (R2)
APOLIPOPROTEIN AI/B CALIBRATOR KAI-008C 1x1 mL Lyophilized; 2x2 mL Diluent
APOLIPOPROTEIN AII/ CII/ CIII CALIBRATOR KAI-041C 1 x 1 mL Lyophilized, 2 x 2 mL Diluent
APOLIPOPROTEIN CONTROLS K112C-4M L1 2x1mL; L2 2x1mL
APOLIPOPROTEIN E MULTI-CALIBRATORS KAI-025C 1x1 mL Lyophilized; 2x2 mL Diluent

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